منابع مشابه
Aging and cancer cell biology, 2009.
Cancer is an age-related disease in organisms with renewable tissues. A malignant tumor arises in part from genomic damage, which can also drive age-related degeneration. However, cancer differs from many age-related degenerative diseases in that it entails gain-of-function changes that confer new (albeit aberrant) properties on cells, resulting in vigorous cell proliferation and survival. None...
متن کاملBiology of aging and cancer.
BACKGROUND The incidence of cancer increases with age in both humans and laboratory animals. A clear understanding of the causes of the age-related increase in cancer incidence is needed to develop a strategy for primary cancer prevention. METHODS We summarized the data available in the literature and our own experience in hormonal metabolic shifts in organisms and disturbances at tissue and ...
متن کاملThe cell biology of aging
One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal--a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts. We now have evidence that aging is instead at least in part genetically regulated. Many mutations have been discovered to extend lifespan in organis...
متن کاملThe Cell Biology of Aging
The distinction between the effects of aging as a chronological process and diseases whose prevalence increase with advancing age remains blurred. Conditions once thought to be inevitable companions of old age are now known to in fact be pathological in origin and thus possibly treatable and preventable. One example is senile dementia, no longer the mysterious fate of the very old, but often a ...
متن کاملCell biology of disease and aging: a two-way street
The Cellular Mechanisms of Disease and Aging Minisymposium featured studies investigating human disease and aging in a wide variety of model systems. Four talks highlighted disease mechanisms. Benoît Renvoisé (National Institutes of Health) described a mouse model for Troyer syndrome (SPG20), an autosomal recessive hereditary spastic paraplegia. Spg20 −/− knockout mice lacking the spartin prote...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2008
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2008.00383.x